PUBLICATIONS
Publications and Data:
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Supplementary Data
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- - Papers:
- - 2009 - -
Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxi
Essential role for TRPC5 in amygdala function and fear-related behavior
TRPM1 forms ion channels associated with melanin content in melanocytes
Intracellular calcium strongly potentiates agonist-activated TRPC5 channels
- - 2008 - -
TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane.
Citral sensing by transient receptor potential channels in dorsal root ganglion
Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Alteri
Transient Receptor Potential (TRP) Channels
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of
- - 2007 - -
All four CatSper ion channel proteins are required for male fertility and sperm
TRPC Canonical (Short) TRP Channel Table
TRP Channels Table - TRPA (Ankyrin), TRPP (Polycystins), TRPML (mucolipins)
TRPM Channel Family (Melastatin-Related, Long TRPs) Table
TRPV Channel Family (Vanilloid) Table
KSper, a pH-sensitive K+ current that controls sperm membrane potential.
CatSper beta: A novel transmembrane protein in the CatSper channel complex
Activating mutation in a mucolipin transient receptor potential channel leads to
- - 2006 - -
Functional TRPM7 channels accumulate at the plasma membrane in response to fluid
Whole-cell patch-clamp measurements of spermatazoa reveal an alkaline-activated
International Union of Pharmacology. XLIX. Nomenclature and structure-function r
An Introduction to TRP Channels
Flavors and skin sensitizers activate specific TRP channels.
A voltage-gated proton-selective channel lacking the pore domain.
Bisandrographalide from Andrographis Paniculata activates TRPV4 channels
The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects tr
- - 2005 - -
TRPC6 is a glomerular slit diaphragm-associated channel requiredd for normal ren
TRP channels and mice deficient in TRP channels.
TATA-Binding Protein (TBP)-Like Factor (TLF) Is a Functional Regulator of Transc
Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Van
International Union of Pharmacology. XLIX. Nomenclature and structure-function r
International Union of Pharmacology. LIV. Nomenclature and Molecular Relationsh
- - 2004 - -
A Superfamily of Voltage-gated Sodium Channels in Bacteria
The mitochondrial calcium uniporteris a highly selective ion channel
A spontaneous, recurrent mutation in Divalent Metal Transporter-1 exposes a calc
TRP ion channels in the nervous system
The voltage-gated Na+ channel NaVBP has a rolein motility, chemotaxis, and pH h
Rapid vesicular translocation and insertion ofTRP channels
SynGAP-MUPP1-CaMKII Synaptic Complexes Regulatep38 MAP Kinase Activity and NMDA
Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Medi
- - 2003 - -
Real-Time Imaging of Nuclear Permeation by EGFP in Single
Mechanism of Persistent Protein Kinase D1 Translocation and Activation
Formation of novel TRPC channels by complex subunit interactions in embryonic br
The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Br
Transient Receptor Potential Ion Channels
CatSper1 required for evoked Ca2+ entry and control of flagellar function in spe
TRP channels as cellular sensors
Symmetry, Selectivity, and the 2003 Nobel Prize
TRP CHANNELS
A superfamily of voltage-gated sodium channels in bacteria.
International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Chann
International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Cha
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-
- - 2002 - -
Hot and cold ion channels
Structural characterization of the mouse Girk genes
The TRPM7 channel is inactivated by PIP2 hydrolysis
Supplementary data to Xu, Ramsey, Kotecha et al
TRPV3 is a calcium-permeable temperature-sensitive cation channel
Sorting out MIC, TRP, and CRAC ion channels
The cation selectivity filter of the bacterial sodium channel, NaChBac.
Modified herpes simplex virus delivery of enhanced GFP into the central nervous
The TRP Ion Channel Family
A voltage-gated ion channel expressed specifically in spermatozoa
- - 2001 - -
TRP-PLIK, a bifunctional protein with kinase and ion channel activities
TRPC1 and TRPC5 form a novel cation channel in mammalian brain
CaT1 manifests the pore properties of the calcium-release-activated calcium chan
How to lose your hippocampus by working on chloride channels
The stoichiometry of G-beta/gamma binding G-protein-regulated inwardly rectifyin
Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the majo
Evaluation of the role of I-kach in atrial fibrillation using a mouse knockout m
A sperm ion channel required for sperm motility and male fertility
The TRP ion channel family
A prokaryotic voltage-gated sodium channel
- - 2000 - -
Function and biochemical evidence for G-protein-gated inwardly rectifying K+ (GI
Distinct ion channel classes are expressed in the outer nuclear envelope of T- a
A switch mechanism for G-beta/gamma activation of I-kach
Brain localization and behavioral impact of the G-protein-gated K+ channel subun
ICln is essential for cellular and early embryonic viability
- - 1999 - -
Molecular determinants for subcellular localization of PSD-95 with an interactin
More pieces of the K+ ion channel puzzle
Functional expression and characterization of G-protein gated inwardly rectifyin
GIRK4 confers appropriate processing and cell surface localization to G-protein-
G-beta/gamma binding increases the open time of Ikach: kinetic evidence for mult
Conformational changes of the in situ nuclear pore complex
- - 1998 - -
pICln binds to a mammalian homolog of a yeast protein involved in regulation of
A novel inward rectifier K+ channel with unique pore properties
NMDA receptors amplify calcium influx into dendritic spines during associative p
Active nuclear import and export is independent of lumenal Ca2+ stores in intact
Abnormal heart rate regulation in GIRK4 knockout mice
Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK
Number and stoichiometry of subunits in the native atrial G-protein-gated K+ cha
Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+
G beta/gamma binding to GIRK4 subunit is critical for G-protein-gated K+ channel
- - 1997 - -
Ion Channels: Basic Science and Clinical Disease
- - 1996 - -
Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits
Non-selective and G beta/gamma insensitive weaver K+ channels
Conformational states of the nuclear pore complex induced by depletion of nuclea
- - 1995 - -
Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+
The G-protein gated atrial K+ channel Ikach is a heterodimer of two inwardly rec
G-beta/gamma binds directly to the G-protein gated K+ channel, Ikach
The G protein beta/gamma subunit transduces the muscarinic receptor signal for C
Calcium release from the nucleus by pIns3 Receptor Channels
Calcium Signalling: Review
- - 1994 - -
Molecular characterization of a swelling-induced chloride conductance regulatory
Recombinant G-protein beta/gamma subunits activate the muscarinic-gated atrial p
- - 1993 - -
Optical modifications enabling simultaneous confocal imaging with dyes excited b
Acceleration of intracellular calcium waves in xenopus oocytes by calcium influx
- - 1992 - -
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+ permeable chann
New mammalian chloride channel identified by expression cloning
- - 1991 - -
Cloning and expression of a rat cardiac delayed rectifier potassium channel
Chloride channels in the nuclear membrane
Spiral calcium wave propagation and annihilation in xenopus laevis oocytes
Subcellular patterns of calcium release determined by G protein specific residue
- - 1989 - -
Potassium channels in cardiac cells activated by arachidonic acid and phospholip
G protein betagamma subunits activate the cardiac muscarinic K channel via PLA2
- - 1988 - -
Specificity of action of guanine nucelotide-binding regulatory protein subunits
Haemodynamic shear stress activates a K+ current in vascular endothelial cells
- - 1987 - -
The Beta/Gamma subunits of GTP-binding protein activate the muscarinic K+ channe
- - 1985 - -
Gamma Aminobutyric acid receptor channels in adrenal chromaffin cells: A patch c
- - 1984 - -
Development of a delayed outward-rectifying K+ conductance in cultured mouse per
TRIFLUOPERAZINE REDUCES INWARD IONIC CURRENTS AND SECRETION BY SEPARATE MECHANIS
SUBSTANCE P REDUCES ACETYLCHOLINEINDUCED CURRENTS IN ISOLATED BOVINE CHROMAFFIN
Publications Table
Supplemental Data
RESOURCES
TRP Channel Tables
TRPC Family
TRPM Family
TRPV Family
Others: TRPA, TRPP, TRPML
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ABOUT THE LAB
Our Research:
Calcium Signalling
Channels and Fertility
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Ion Channels that Control Fertility
Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This technical advance, combined with genetic deletion strategies, makes unambiguous identification of sperm ion channel currents possible. This review summarizes the ion channel currents that have been directly measured in mammalian sperm, and their physiological roles in fertilization. The predominant currents are 1) a Ca
2+
-selective current requiring expression of the 4 mCatSper genes, and 2) a delayed rectifier K
+
current with properties most similar to mSlo3. Intracellular alkalinization activates both channels and induces hyperactivated motility.
For an in-depth review, read our recent article:
Ion Channels that Control Fertility in Mammalian Spermatozoa
.
CONTACT US
E-mail General Inquiries
Michelle Estrada Merry
Address:
David E. Clapham MD, PhD.
Howard Hughes Medical Institute
Department of Cardiology
,
Children's Hospital
Department of Neurobiology
,
Harvard Medical School
1309 Enders Research Building
320 Longwood Avenue
Boston, MA 02115
Phone
: 617-919-2680
FAX
: 617-731-0787
E-Mail
:
David E Clapham
NEWS
Welcome to the new Clapham Lab website! Feedback is welcome; direct to General Inquiries.
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