PUBLICATIONS Publications and Data: - - - - - - - Supplementary Data - - - - - - - - - Papers: - - 2009 - - Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxiEssential role for TRPC5 in amygdala function and fear-related behaviorTRPM1 forms ion channels associated with melanin content in melanocytesIntracellular calcium strongly potentiates agonist-activated TRPC5 channels - - 2008 - - TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Citral sensing by transient receptor potential channels in dorsal root ganglion Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without AlteriTransient Receptor Potential (TRP) ChannelsEvolutionary genomics reveals lineage-specific gene loss and rapid evolution of - - 2007 - - All four CatSper ion channel proteins are required for male fertility and sperm TRPC Canonical (Short) TRP Channel TableTRP Channels Table - TRPA (Ankyrin), TRPP (Polycystins), TRPML (mucolipins)TRPM Channel Family (Melastatin-Related, Long TRPs) TableTRPV Channel Family (Vanilloid) TableKSper, a pH-sensitive K+ current that controls sperm membrane potential. CatSper beta: A novel transmembrane protein in the CatSper channel complexActivating mutation in a mucolipin transient receptor potential channel leads to - - 2006 - - Functional TRPM7 channels accumulate at the plasma membrane in response to fluidWhole-cell patch-clamp measurements of spermatazoa reveal an alkaline-activated International Union of Pharmacology. XLIX. Nomenclature and structure-function rAn Introduction to TRP ChannelsFlavors and skin sensitizers activate specific TRP channels.A voltage-gated proton-selective channel lacking the pore domain.Bisandrographalide from Andrographis Paniculata activates TRPV4 channels The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects tr - - 2005 - - TRPC6 is a glomerular slit diaphragm-associated channel requiredd for normal renTRP channels and mice deficient in TRP channels.TATA-Binding Protein (TBP)-Like Factor (TLF) Is a Functional Regulator of TranscCamphor Activates and Strongly Desensitizes the Transient Receptor Potential VanInternational Union of Pharmacology. XLIX. Nomenclature and structure-function r International Union of Pharmacology. LIV. Nomenclature and Molecular Relationsh - - 2004 - - A Superfamily of Voltage-gated Sodium Channels in BacteriaThe mitochondrial calcium uniporteris a highly selective ion channelA spontaneous, recurrent mutation in Divalent Metal Transporter-1 exposes a calcTRP ion channels in the nervous systemThe voltage-gated Na+ channel NaVBP has a rolein motility, chemotaxis, and pH hRapid vesicular translocation and insertion ofTRP channelsSynGAP-MUPP1-CaMKII Synaptic Complexes Regulatep38 MAP Kinase Activity and NMDA Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Medi - - 2003 - - Real-Time Imaging of Nuclear Permeation by EGFP in SingleMechanism of Persistent Protein Kinase D1 Translocation and ActivationFormation of novel TRPC channels by complex subunit interactions in embryonic brThe NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction betweenTRPC5 is a regulator of hippocampal neurite length and growth cone morphologyFormation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic BrTransient Receptor Potential Ion ChannelsCatSper1 required for evoked Ca2+ entry and control of flagellar function in speTRP channels as cellular sensorsSymmetry, Selectivity, and the 2003 Nobel PrizeTRP CHANNELS A superfamily of voltage-gated sodium channels in bacteria.International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion ChannInternational Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion ChaInternational Union of Pharmacology: Approaches to the Nomenclature of Voltage- - - 2002 - - Hot and cold ion channelsStructural characterization of the mouse Girk genesThe TRPM7 channel is inactivated by PIP2 hydrolysisSupplementary data to Xu, Ramsey, Kotecha et alTRPV3 is a calcium-permeable temperature-sensitive cation channel Sorting out MIC, TRP, and CRAC ion channels The cation selectivity filter of the bacterial sodium channel, NaChBac. Modified herpes simplex virus delivery of enhanced GFP into the central nervous The TRP Ion Channel FamilyA voltage-gated ion channel expressed specifically in spermatozoa - - 2001 - - TRP-PLIK, a bifunctional protein with kinase and ion channel activitiesTRPC1 and TRPC5 form a novel cation channel in mammalian brainCaT1 manifests the pore properties of the calcium-release-activated calcium chanHow to lose your hippocampus by working on chloride channelsThe stoichiometry of G-beta/gamma binding G-protein-regulated inwardly rectifyinFundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the majoEvaluation of the role of I-kach in atrial fibrillation using a mouse knockout mA sperm ion channel required for sperm motility and male fertilityThe TRP ion channel familyA prokaryotic voltage-gated sodium channel - - 2000 - - Function and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIDistinct ion channel classes are expressed in the outer nuclear envelope of T- aA switch mechanism for G-beta/gamma activation of I-kachBrain localization and behavioral impact of the G-protein-gated K+ channel subunICln is essential for cellular and early embryonic viability - - 1999 - - Molecular determinants for subcellular localization of PSD-95 with an interactinMore pieces of the K+ ion channel puzzleFunctional expression and characterization of G-protein gated inwardly rectifyinGIRK4 confers appropriate processing and cell surface localization to G-protein-G-beta/gamma binding increases the open time of Ikach: kinetic evidence for multConformational changes of the in situ nuclear pore complex - - 1998 - - pICln binds to a mammalian homolog of a yeast protein involved in regulation of A novel inward rectifier K+ channel with unique pore propertiesNMDA receptors amplify calcium influx into dendritic spines during associative pActive nuclear import and export is independent of lumenal Ca2+ stores in intactAbnormal heart rate regulation in GIRK4 knockout miceIdentification of native atrial G-protein-regulated inwardly rectifying K+ (GIRKNumber and stoichiometry of subunits in the native atrial G-protein-gated K+ chaLocalization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+G beta/gamma binding to GIRK4 subunit is critical for G-protein-gated K+ channel - - 1997 - - Ion Channels: Basic Science and Clinical Disease - - 1996 - - Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits Non-selective and G beta/gamma insensitive weaver K+ channelsConformational states of the nuclear pore complex induced by depletion of nuclea - - 1995 - - Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+The G-protein gated atrial K+ channel Ikach is a heterodimer of two inwardly recG-beta/gamma binds directly to the G-protein gated K+ channel, IkachThe G protein beta/gamma subunit transduces the muscarinic receptor signal for CCalcium release from the nucleus by pIns3 Receptor ChannelsCalcium Signalling: Review - - 1994 - - Molecular characterization of a swelling-induced chloride conductance regulatoryRecombinant G-protein beta/gamma subunits activate the muscarinic-gated atrial p - - 1993 - - Optical modifications enabling simultaneous confocal imaging with dyes excited bAcceleration of intracellular calcium waves in xenopus oocytes by calcium influx - - 1992 - - Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+ permeable channNew mammalian chloride channel identified by expression cloning - - 1991 - - Cloning and expression of a rat cardiac delayed rectifier potassium channelChloride channels in the nuclear membraneSpiral calcium wave propagation and annihilation in xenopus laevis oocytesSubcellular patterns of calcium release determined by G protein specific residue - - 1989 - - Potassium channels in cardiac cells activated by arachidonic acid and phospholipG protein betagamma subunits activate the cardiac muscarinic K channel via PLA2 - - 1988 - - Specificity of action of guanine nucelotide-binding regulatory protein subunits Haemodynamic shear stress activates a K+ current in vascular endothelial cells - - 1987 - - The Beta/Gamma subunits of GTP-binding protein activate the muscarinic K+ channe - - 1985 - - Gamma Aminobutyric acid receptor channels in adrenal chromaffin cells: A patch c - - 1984 - - Development of a delayed outward-rectifying K+ conductance in cultured mouse perTRIFLUOPERAZINE REDUCES INWARD IONIC CURRENTS AND SECRETION BY SEPARATE MECHANISSUBSTANCE P REDUCES ACETYLCHOLINEINDUCED CURRENTS IN ISOLATED BOVINE CHROMAFFIN  Publications Table Supplemental Data RESOURCES TRP Channel Tables TRPC Family TRPM Family TRPV Family Others: TRPA, TRPP, TRPML MTA/Clone Requests Send all forms w/ request: HHMI ShortMTA Reagent Requests ABOUT THE LAB Our Research: Calcium Signalling Channels and Fertility Media: Video Figures The Lab: Lab Facilities Lab Members To view a paper in PDF form, click on its "PDF" link on the right side of the table. Sort papers by category by clicking on the category name (eg. "Authors"). Download Adobe Acrobat to view the PDF files. To reference TRP Channel Tables, please use "Clapham, DE, (Year). Clapham Lab Publications, http://clapham.tch.harvard.edu". Title Author(s) Journal Year PDF HTML Supp Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst Ramsey, Ruchti, Kaczmarek, Clapham PNAS 2009 PDF Essential role for TRPC5 in amygdala function and fear-related behavior Riccio et al Cell 2009 PDF TRPM1 forms ion channels associated with melanin content in melanocytes Oancea, E. Vriens, J. Brauchi, S. et al. Sci Signal 2009 PDF Intracellular calcium strongly potentiates agonist-activated TRPC5 channels Blair, N. T. Kaczmarek, J. S. et al. J Gen Physiol 2009 PDF TRPM7 facilitates cholinergic vesicle fusion with the plasma membrane. Brauchi S, Krapivinsky G, Krapivinsky L, et al. PNAS 2008 PDF Citral sensing by transient receptor potential channels in dorsal root ganglion neurons. Stotz, SC, Vriens, J, Martyn, D, et al. PLoS One 2008 PDF Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg2+ Homeostasis Jie Jin,Bimal N. Desai, Betsy Navarro, et al. Science 2008 PDF Transient Receptor Potential (TRP) Channels Clapham, DE Encyclopedia of Neuroscience 2008 PDF Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSper beta Cai, X and Clapham, DE PLoS One 2008 PDF All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility. Qi, H, Moran, MM, Navarro, B, et al. PNAS 2007 PDF TRPC Canonical (Short) TRP Channel Table Clapham Lab Clapham Lab 2007 PDF TRP Channels Table - TRPA (Ankyrin), TRPP (Polycystins), TRPML (mucolipins) Clapham Lab Clapham Lab 2007 PDF TRPM Channel Family (Melastatin-Related, Long TRPs) Table Clapham Lab Clapham Lab 2007 PDF TRPV Channel Family (Vanilloid) Table Clapham Lab Clapham Lab 2007 PDF KSper, a pH-sensitive K+ current that controls sperm membrane potential. Navarro, B, Kirichok, Y, and Clapham, et al. PNAS 2007 PDF CatSper beta: A novel transmembrane protein in the CatSper channel complex Jin Liu, Jingsheng Xia, Kwang-Hyun Cho, et al. JBC 2007 PDF Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint–waddler mice Xu, Delling, Li, Dong, Clapham PNAS 2007 PDF Functional TRPM7 channels accumulate at the plasma membrane in response to fluid flow Elena Oancea, Joshua Wolfe, David E. et al. Circulation Research 2006 PDF Whole-cell patch-clamp measurements of spermatazoa reveal an alkaline-activated Ca channel Yuriy Kirichok, Betsy Navarro, and David et al. Nature 2006 PDF International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels Clapham, DE, Julius, DJ, Montell, C, et al. Pharm Rev 2006 PDF An Introduction to TRP Channels I. Scott Ramsey, Markus Delling, and et al. Annual Reviews of Physiology 2006 PDF Flavors and skin sensitizers activate specific TRP channels. Xu, Delling, Jun, Clapham Nature Neuroscience 2006 PDF A voltage-gated proton-selective channel lacking the pore domain. Ramsey, Moran, Chong, Clapham Nature 2006 PDF Bisandrographalide from Andrographis Paniculata activates TRPV4 channels Smith, Maloney, Pothen, Clardy, Clapham Journal of Biological Chemistry 2006 PDF HTML The TRPM7 ion channel functions in cholinergic synaptic vesicles and affects transmitter release. Krapivinsky, G, Mochida, S, Krapivinsky, L, et al. Neuron 2006 PDF TRPC6 is a glomerular slit diaphragm-associated channel requiredd for normal renal function Reiser, Polu, Moller, Kenlan, Altintas, Wei, et al. Nature Genetics 2005 PDF TRP channels and mice deficient in TRP channels. Desai, B and Clapham, DE Pfluegers’ Arch Eur. J Physiol, 2005 PDF TATA-Binding Protein (TBP)-Like Factor (TLF) Is a Functional Regulator of Transcription: Reciprocal Regulation of the Neurofibromatosis Type 1 and c-fos Genes by TLF/TRF2 and TBP Jayhong A. Chong, Magdalene M. Moran, et al. MOLECULAR AND CELLULAR BIOLOGY, 2005 PDF Suppl. Data Camphor Activates and Strongly Desensitizes the Transient Receptor Potential Vanilloid Subtype 1 Channel in a Vanilloid-Independent Mechanism Haoxing Xu, Nat Blair, and David et al. Journal of Neuroscience 2005 PDF International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of of CatSper and Two-Pore Channels. Clapham, DE, and Garbers, DL Pharmacol Rev. 2005 PDF International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels Kubo, Y, Adelman, JP, Clapham, DE, et al. Pharmacol Rev. 2005 PDF A Superfamily of Voltage-gated Sodium Channels in Bacteria Ryuta Koishi, Haoxing Xu, Dejian Ren, et al. Journal of Biological Chemistry 2004 PDF The mitochondrial calcium uniporteris a highly selective ion channel Yuriy Kirichok, Grigory Krapivinsky & David et al. Nature 2004 PDF A spontaneous, recurrent mutation in Divalent Metal Transporter-1 exposes a calcium entry pathway in Divalent Metal Transporter-1 Exposes a Calcium Entry Pathway Haoxing Xu, Jie Jin, Louis et al. Public Library of Science (PLoS) 2004 PDF TRP ion channels in the nervous system Magdalene M Moran, Haoxing Xu and et al. Current Opinions in Neurobiology 2004 PDF The voltage-gated Na+ channel NaVBP has a rolein motility, chemotaxis, and pH homeostasisof an alkaliphilic Bacillus Masahiro Ito, Haoxing Xu, Arthur A. et al. PNAS 2004 PDF Rapid vesicular translocation and insertion ofTRP channels Vassilios J. Bezzerides, I. Scott Ramsey, et al. Nature Cell Biology 2004 PDF SynGAP-MUPP1-CaMKII Synaptic Complexes Regulatep38 MAP Kinase Activity and NMDA Receptor-Dependent Synaptic AMPA Receptor Potentiation Grigory Krapivinsky, Igor Medina,Luba Krapivinsky, Svetlana et al. Neuron 2004 PDF Phosphatidylinositol 3-Kinase Activates ERK in Primary Sensory Neurons and Mediates Inflammatory Heat Hyperalgesia through TRPV1 Sensitization Zhi-Ye Zhuang, Haoxing Xu, David E. et al. The Journal of Neuroscience 2004 PDF Real-Time Imaging of Nuclear Permeation by EGFP in Single Xunbin Wei, Vanessa G. Henke, Carsten et al. Biophysical Journal 2003 PDF Mechanism of Persistent Protein Kinase D1 Translocation and Activation Elena Oancea, Vassilios J. Bezzerides, Anna et al. Developmental Cell 2003 PDF Formation of novel TRPC channels by complex subunit interactions in embryonic brain Carsten Strübing, Grigory Krapivinsky, Luba Krapivinsky, et al. The Journal of Biological Chemistry 2003 PDF The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1 Krapivinsky, Krapivinsky, Manasian, Ivanov, Tyzio, Pellegrino, et al. Neuron 2003 PDF TRPC5 is a regulator of hippocampal neurite length and growth cone morphology Greka, A, Navarro, B, Oancea, E, et al. Nature Neuroscience 2003 PDF Formation of Novel TRPC Channels by Complex Subunit Interactions in Embryonic Brain Carsten Struebing, Grigory Krapivinsky, Luba Krapivinsky, et al. The Journal of Biological Chemistry 2003 PDF Transient Receptor Potential Ion Channels Clapham, Julius, Montell, Schultz IUPHAR Compendium 2003 PDF CatSper1 required for evoked Ca2+ entry and control of flagellar function in sperm. Carlson, AE, Westenbroek, RE, Quill, T, et al. PNAS 2003 PDF TRP channels as cellular sensors Clapham, DE Nature 2003 PDF Symmetry, Selectivity, and the 2003 Nobel Prize Clapham, DE Cell 2003 PDF TRP CHANNELS Clapham, DE For Clapham WEB site clapham.tch.harvard.edu 2003 PDF A superfamily of voltage-gated sodium channels in bacteria. Koishi, R, Xu, H, Ren, D, et al. The Journal of Biological Chemistry 2003 PDF International Union of Pharmacology. XLI. Compendium of Voltage-Gated Ion Channels: Potassium Channels GEORGE A. GUTMAN, K. GEORGE CHANDY, et al. PHARMACOLOGICAL REVIEWS 2003 PDF International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels DAVID E. CLAPHAM, CRAIG MONTELL, GUENTER et al. PHARMACOLOGICAL REVIEWS 2003 PDF International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels W. A. CATTERALL, K. G. CHANDY, et al. PHARMACOLOGICAL REVIEWS 2003 PDF Hot and cold ion channels Clapham Science 2002 PDF Structural characterization of the mouse Girk genes Wickman, Pu, and Clapham Gene 2002 PDF The TRPM7 channel is inactivated by PIP2 hydrolysis Runnels, L, Yue, L, and Clapham, et al. Nature Cell Biology 2002 PDF Supplementary data to Xu, Ramsey, Kotecha et al Xu, Ramsey, Kotecha et al Nature 2002 PDF TRPV3 is a calcium-permeable temperature-sensitive cation channel Haoxing Xu, I. Scott Ramsey, et al. Nature 2002 PDF Sorting out MIC, TRP, and CRAC ion channels Clapham, DE The Journal of General Physiology 2002 PDF The cation selectivity filter of the bacterial sodium channel, NaChBac. Yue, L, Navarro, B, Ren, et al. The Journal of General Physiology, 2002, DOI:10.1085/jgp 20028699. 2002 PDF Modified herpes simplex virus delivery of enhanced GFP into the central nervous system Sandler, V, Wang, S, Angelo, K, et al. Journal of Neuroscience Methods 2002 PDF The TRP Ion Channel Family Clapham, DE, Montell, C, Schultz, G, et al. IUPHAR Compendium 2002 PDF A voltage-gated ion channel expressed specifically in spermatozoa Timothy A. Quill, Dejian Ren, David et al. Proceedings of the National Academy of Sciences 2002 PDF TRP-PLIK, a bifunctional protein with kinase and ion channel activities Runnels, Yue, Clapham Science 2001 PDF TRPC1 and TRPC5 form a novel cation channel in mammalian brain Strübing, Krapivinsky, Krapivinsky, Clapham Neuron 2001 PDF CaT1 manifests the pore properties of the calcium-release-activated calcium channel Yue, Peng, Hediger, Clapham Nature 2001 PDF How to lose your hippocampus by working on chloride channels Clapham Neuron 2001 PDF The stoichiometry of G-beta/gamma binding G-protein-regulated inwardly rectifying K+ channels (GIRKs) Corey, Clapham JBC 2001 PDF Fundamental Ca2+ signaling mechanisms in mouse dendritic cells: CRAC is the major Ca2+ entry pathway Hsu, O'Connell, Klyachko, et al. J Immunol 2001 PDF Evaluation of the role of I-kach in atrial fibrillation using a mouse knockout model Kovoor, Wickman, Maguire, et al. J Amer Coll Cardio 2001 PDF A sperm ion channel required for sperm motility and male fertility Ren, Navarro, Perez, et al. Nature 2001 PDF The TRP ion channel family Clapham, Runnels, and Strubing Nature 2001 PDF A prokaryotic voltage-gated sodium channel Ren, Navarro, Xu, Yu, Shi, and et al. Science 2001 PDF Function and biochemical evidence for G-protein-gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK3 Jelacic, Kennedy, Wickman, Clapham JBC 2000 PDF Distinct ion channel classes are expressed in the outer nuclear envelope of T- and B-lymphocyte cell lines Franco-Obregon, Wang, Clapham Biophys J 2000 PDF A switch mechanism for G-beta/gamma activation of I-kach Medina, Krapivinsky, Arnold, et al. JBC 2000 PDF Brain localization and behavioral impact of the G-protein-gated K+ channel subunit GIRK4 Wickman, Karschin, Karschin, Picciotto. Clapham J Neurosci 2000 PDF ICln is essential for cellular and early embryonic viability Pu, Wickman J Biol Chem 2000 PDF Molecular determinants for subcellular localization of PSD-95 with an interacting K+ channel Arnold, Clapham Neuron 1999 PDF More pieces of the K+ ion channel puzzle Clapham Nature Struct Bio 1999 PDF Functional expression and characterization of G-protein gated inwardly rectifying K+ channels containing GIRK3 Jelacic, Sims J Memb Biol 1999 PDF GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels Kennedy, Nemec, Corey, Wickman JBC 1999 PDF G-beta/gamma binding increases the open time of Ikach: kinetic evidence for multiple G-beta/gamma binding sites Nemec, Wickman Biophys J 1999 PDF Conformational changes of the in situ nuclear pore complex Wang, Clapham Biophys J 1999 PDF pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology Krapivinsky, Wickman, Pu, Krapivinsky JBC 1998 PDF A novel inward rectifier K+ channel with unique pore properties Krapivinsky, Medina, Eng, et al. Neuron 1998 PDF NMDA receptors amplify calcium influx into dendritic spines during associative pre- and post-synaptic activation Schiller, Schiller, Clapham Nature 1998 PDF Active nuclear import and export is independent of lumenal Ca2+ stores in intact mammalian cells Strübing, Clapham J Gen Physiol 1998 PDF Abnormal heart rate regulation in GIRK4 knockout mice Wickman, Nemec, Gendler Neuron 1998 PDF Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers Corey, Clapham JBC 1998 PDF Number and stoichiometry of subunits in the native atrial G-protein-gated K+ channle, Ikach Corey, Krapivinsky, Krapivinsky JBC 1998 PDF Localization and interaction of epitope-tagged GIRK1 and CIR inward rectifier K+ channel subunits Kennedy, Nemec Neuropharm 1998 PDF G beta/gamma binding to GIRK4 subunit is critical for G-protein-gated K+ channel activation Krapivinsky, Kennedy, Nemec, et al. JBC 1998 PDF Ion Channels: Basic Science and Clinical Disease Ackerman, M, and Clapham DE New England Journal of Medicine 1997 PDF Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of Ikach currents in oocytes Hedin, Lim, Clapham Neuron 1996 PDF Non-selective and G beta/gamma insensitive weaver K+ channels Navarro, Kennedy, Velimirovic, et al. Science 1996 PDF Conformational states of the nuclear pore complex induced by depletion of nuclear Ca2+ stores Perez-Terzic, Pyle, Jaconi, Stehno-Bittel Science 1996 PDF Diffusion across the nuclear envelope inhibited by depletion of the nuclear Ca2+ store Stehno-BIttel, Perez-Terzic Science 1995 PDF The G-protein gated atrial K+ channel Ikach is a heterodimer of two inwardly rectifying K+ channel proteins Krapivinky, Gordon, Wickman, et al. Nature 1995 PDF G-beta/gamma binds directly to the G-protein gated K+ channel, Ikach Krapivinsky, Krapivinsky, Wickman J Biol Chem 1995 PDF The G protein beta/gamma subunit transduces the muscarinic receptor signal for Ca2+ release in xenopus oocytes Stehno-BIttel, Krapivinksy, Krapivinksy, Perez-Terzic J Biol Chem 1995 PDF Calcium release from the nucleus by pIns3 Receptor Channels Stehno-BIttel, Luckhoff Neuron 1995 PDF Calcium Signalling: Review Clapham Cell 1995 PDF Molecular characterization of a swelling-induced chloride conductance regulatory protein, pICln Krapivinsky, Ackerman, Gordon, Krapivinsky Cell 1994 PDF Recombinant G-protein beta/gamma subunits activate the muscarinic-gated atrial potassium channel Wickman, Iniguez-Liuhl, Davenport, et al. Nature 1994 PDF Optical modifications enabling simultaneous confocal imaging with dyes excited by ultraviolet- and visible-wavelength light Bliton, Lechleiter J Microscopy 1993 PDF Acceleration of intracellular calcium waves in xenopus oocytes by calcium influx Girard, Clapham Science 1993 PDF Video Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca2+ permeable channel Luckhoff, Clapham Nature 1992 PDF New mammalian chloride channel identified by expression cloning Paulmichl, M, Li, Y, Wickman, K, et al. Nature 1992 PDF Cloning and expression of a rat cardiac delayed rectifier potassium channel Paulmichl, Nasmith, Hellmiss, et al. PNAS 1991 PDF Chloride channels in the nuclear membrane Tabares, Mazzanti, Clapham J Memb Biol 1991 PDF Spiral calcium wave propagation and annihilation in xenopus laevis oocytes Lechleiter, Girard, Peralta, Clapham Science 1991 PDF Subcellular patterns of calcium release determined by G protein specific residues of muscarinic receptors Lechleiter, J, Girard, S, Clapham, DE, et al. Nature 1991 PDF Potassium channels in cardiac cells activated by arachidonic acid and phospholipids Kim, Clapham Science 1989 PDF G protein betagamma subunits activate the cardiac muscarinic K channel via PLA2 Kim, D, Lewis, DL, Graziadei, L, et al. Nature 1989 PDF Specificity of action of guanine nucelotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel Logothetis, Kim, Northup, Neer PNAS 1988 PDF Haemodynamic shear stress activates a K+ current in vascular endothelial cells Olesen, Clapham Nature 1988 PDF The Beta/Gamma subunits of GTP-binding protein activate the muscarinic K+ channel in the heart Logothetis, Kurachi, Galper, Neer, Clapham Nature 1987 PDF Gamma Aminobutyric acid receptor channels in adrenal chromaffin cells: A patch clamp study Bormann and Clapham PNAS 1985 PDF Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages Ypey and Clapham PNAS 1984 PDF TRIFLUOPERAZINE REDUCES INWARD IONIC CURRENTS AND SECRETION BY SEPARATE MECHANISMS IN BOVINE CHROMAFFIN CELLS Clapham, DE and Neher, E Journal of Physiology 1984 PDF SUBSTANCE P REDUCES ACETYLCHOLINEINDUCED CURRENTS IN ISOLATED BOVINE CHROMAFFIN CELLS Clapham, DE and Neher, E Journal of Physiology 1984 PDF CONTACT US E-mail General Inquiries Michelle Estrada Merry Address: David E. Clapham MD, PhD. Howard Hughes Medical Institute Department of Cardiology, Children's Hospital Department of Neurobiology, Harvard Medical School 1309 Enders Research Building 320 Longwood Avenue Boston, MA 02115 Phone: 617-919-2680 FAX: 617-731-0787 E-Mail: David E Clapham NEWS Welcome to the new Clapham Lab website! Feedback is welcome; direct to General Inquiries. TRP Channel Tables available in Resources. MTA (Material) / Clone Request forms available in Resources. Administration Panel

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