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eurotransmitters, hormones, and
pharmacologic agents act by binding specific receptors or ion channels on the
cell surface. We are interested in the structure and function of ion channels,
their physiological function, and the signal transduction pathways with which
they interact.
Molecules in the cell membrane that relay hormonal and neurotransmitter signals
bind to receptors on the cell surface (M2, M3) that initiate signalling
cascades involving TRP or potassium channels, or calcium release. M2: Muscarinic
type 2 acetylcholine (ACh) receptor. M3: Muscarinic type 3 ACh receptor. G: G protein.
GIRK: G protein gated inward rectifier channel subunit. PLC: phospholipase C or
PIP2 phosphodiesterase. InsP3:
Inositol (1,4,5) triphosphate. GTP: guanosine triphosphate. GDP: guanosine diphosphate.
DAG: diacylglycerol. TRP: transient receptor potential channel. K+: potassium
selective channel. IP3R: InsP3 receptor.
SERCA: smooth endoplasmic reticulum Ca2+ ATPase pump. + indicates stimulatory regulation.
- indicates inhibition.
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